The Addition of Tissue Stromal Vascular Fraction to Platelet-Rich Plasma Supplemented Lipofilling Does Not Improve Facial Skin Quality: A Prospective Randomized Clinical Trial

Abstract Background Lipofilling has become popular as a treatment to improve aging-related skin characteristics (eg, wrinkles, pigmentation spots, pores, or rosacea). Different additives such platelet-rich plasma (PRP) stromal vascular fraction (SVF) have been combined with lipofilling increase the therapeutic effect of adipose-derived cells (ASCs). Objectives The aim this study was examine hypothesis that mechanically isolated SVF augments PRP-supplemented facial quality. Methods This prospective, double-blind, placebo-controlled, randomized trial conducted between 2016 and 2019. In total, 28 female subjects were enrolled; 25 completed follow-up. All patients received either saline. by fractionation adipose tissue (tSVF). Results evaluated changes in elasticity transepidermal water loss, skin-aging-related features, ie, superficial texture, vascularity, pigmentation, well patient satisfaction (FACE-Q), recovery, number complications up 1 year postoperative. addition tSVF did not elasticity, features. No improvement overall appearance quality seen when added lipofilling. Conclusions comparison lipofilling, does healthy population. can be considered safe procedure. Level Evidence: 2